Transitional Cell Carcinoma (TCC) in Dogs – Symptoms, Surgery, Treatment Methods, Tips for Improvement and CureThe Immune Power to Defeat Bladder Cancer and Transitional Cell Carcinoma

About Bladder Cancer and Transitional Cell Carcinoma in Dogs

The bladder is an organ that stores urine sent from the kidneys. Among tumors occurring there, malignant ones are termed bladder cancer.

Most bladder cancers in dogs originate in the transitional epithelium, known as transitional cell carcinoma.

A majority of tumors in a dog’s bladder are malignant, with benign ones being rare. Malignant tumors, or cancers, grow and metastasize rapidly. If the tumor remains confined within the bladder, it may not immediately threaten life, but if it blocks the ureter, swift action is needed as it can be dangerous.

If you notice suspicious symptoms like blood in the urine, “waiting and seeing” is not appropriate. Take your dog to the vet early. It might just be cystitis, but getting an ultrasound examination provides peace of mind.

Causes, Characteristics, Symptoms of Bladder Cancer in Dogs

Bladder cancer in dogs is often of the “transitional cell carcinoma” type and has a poor prognosis. Due to the similarity in symptoms, diagnosis is often delayed as they can be mistaken for cystitis. Blood in the urine, frequent urination, a hard feeling in the bladder, or pain when touched can be indicators.

The exact cause is unclear. In humans, smoking and inhalation of organic solvents are related to bladder cancer. For animals, avoiding foods with synthetic additives or pesticide residues is advisable. Changing a dog’s diet may be challenging but could aid in treatment.

Diagnostic Methods for Bladder Cancer in Dogs

Initially, external tumor observation is done through X-rays or ultrasound (echo). Some places might use CT scans, though this is not common due to low prevalence. MRI scans are also not common. Incidentally, urine appears white in these scans.

Biopsies are performed to actually collect and confirm cancer cells. Cancer cells can sometimes be seen in the urine but are not always detectable.

Surgery for Bladder Cancer in Dogs

Surgery is generally prioritized if the tumor can be completely removed. Depending on cancer spread, it might involve partial or complete bladder removal.

Bladder nerves are easily damaged during surgery, potentially causing post-operative frequent urination or poor urine flow. Partial removal and consequent bladder reduction can also result in frequent urination.

In cases of total bladder removal, the urinary exit may be rerouted. Urine may be expelled through the skin or bowels, each with its own issues. Consult with your vet.

While surgery offers potential complete tumor removal, it carries significant risks and likely post-operative QOL reduction.

Drug Treatment for Bladder Cancer in Dogs

Chemotherapy may be used. However, solely relying on chemotherapy without surgery to cure bladder cancer is usually impossible. Chemotherapy post-surgery to prevent recurrence shows effectiveness in only a small percentage of cases.
Piroxicam is used for treating bladder cancer in animals. It actually has inhibitory effects on bladder cancer. Due to its much milder side effects compared to anticancer drugs, it is widely used.

The precise mechanism by which piroxicam is effective is not well understood, but it is believed to involve the inhibition of the synthesis of inflammatory substances such as leukotrienes and thromboxanes. Whether other anti-inflammatory drugs have similar effects is not yet clear.

※ Gastrointestinal disturbances caused by piroxicam are a well-known side effect, but hematuria may also occur. When hematuria is present in cases where bladder cancer coexists with cystitis, piroxicam should be used with caution.

If you decide to undergo anticancer drug treatment or piroxicam treatment, it is advisable to incorporate Cordy for immune support and domestically sourced SPF pig placenta extract for liver and kidney care as a countermeasure for side effects.

Improving Prognosis – Canine Bladder Cancer & Transitional Cell Carcinoma

The prognosis of canine bladder cancer and transitional cell carcinoma largely depends on how well recurrence can be prevented. Recurrence refers to the regrowth of cancer that was not completely removed during surgery. Even if all visible cancer is removed surgically, there is a high possibility that small cancer cells may have spread to surrounding or distant organs.

Continuing with strong anticancer drugs for a long time to prevent recurrence carries considerable risks. Using piroxicam, which has a high safety profile, may be a good approach.

*Be cautious of hematuria and liver function decline.

Let’s Work on Improving Immunity

Surgery and chemotherapy often reduce immune function due to high stress and side effects. Moreover, even successful surgery cannot guarantee 100% prevention of recurrence.

We believe that a rapid re-establishment and maintenance of immune strength is crucial to lower recurrence rates.

Immune Measures Are Crucial for Improving Bladder Cancer & Transitional Cell Carcinoma

When your dog is diagnosed with bladder cancer or transitional cell carcinoma, implementing immune measures is vital, regardless of whether you choose to proceed with surgery or chemotherapy.
Cordy offers an immune support solution that does not burden the body.

When treating with chemotherapy, piroxicam, steroids, antibiotics, or other medications, liver care becomes essential. We recommend considering the use of Domestic SPF Pig Placenta Extract Powder for managing side effects.

While the extent of response is uncertain, there is ample possibility for at least an increase in appetite and recovery of vitality.

Our laboratory continues to research Cordy, which has potential immune-modulating effects, and domestic SPF pig-derived placenta extract powder, which may protect liver function. Please contact us if you have any inquiries.

監修獣医師：林美彩　　所属クリニック：chicoどうぶつ診療所

代替療法と西洋医学、両方の動物病院での勤務経験と多数のコルディの臨床経験をもつ。　モノリス在籍時には、一般的な動物医療（西洋医学）だけでは対応が困難な症例に対して多くの相談を受け、免疫の大切さを痛烈に実感する。
ペットたちの健康維持・改善のためには薬に頼った対処療法だけではなく、「普段の生活環境や食事を見直し、自宅でさまざまなケアを取り入れることで免疫力を維持し、病気にならない体づくりを目指していくことが大切である」という考えを提唱し普及活動に従事している。

所属：

• 獣医保健ソーシャルワーク協会

著書：

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