The Liver Function Recovery Effects of Placenta: Improving Liver Function in Dogs and CatsPlacenta for the Liver Health of Dogs and Cats

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Effects of Placenta on the Liver

As discussed in Part 1, placenta can activate liver cells, prevent and remove reactive oxygen species, and has anti-inflammatory effects that can suppress inflammation caused by reactive oxygen species. Therefore, it may be effective in addressing liver dysfunction, hepatitis, and cirrhosis.

Please refer to this explanation about liver functions and liver metrics.

Outlined below are the effects useful for improving liver function.

Hepatoprotective Effects

Three factors that support hepatoprotective effects are 1) Hepatocyte Growth Factor (HGF), 2) Removal of Reactive Oxygen Species, and 3) Anti-inflammatory Effects.
1) HGF promotes the division and proliferation of liver cells and facilitates the breakdown and removal of liver fibrosis.
In cases where hepatitis is present, the function of TGF-β suppresses the secretion of HGF, thereby inhibiting the regeneration of liver cells and promoting liver fibrosis.

However, supplementation of HGF through placenta helps promote the division and proliferation of liver cells while simultaneously suppressing TGF-β, showing the effect of breaking down and removing fibrotic liver tissue.

Placenta also contains TGF-β, which is a crucial element for cell proliferation and differentiation, as well as the formation of fibroblasts necessary for body regeneration. Therefore, having a balanced presence of TGF-β and HGF is considered important.

2) The liver primarily handles metabolism, detoxification, and bile production, but these processes consume a large amount of oxygen, making it prone to the formation of reactive oxygen species. This can lead to oxidative damage to liver cells and a decline in liver function. Placenta can remove these excess reactive oxygen species, thereby protecting liver cells and preventing decreased liver function.

3) Inflammation caused by reactive oxygen species can lead to decreased liver function. If inflammation is prolonged, it may progress to more serious conditions like cirrhosis; therefore, it is crucial to suppress the inflammation early on. Placenta’s anti-inflammatory effects can help prevent the worsening of liver disorders.

Detoxification Effects

The liver detoxifies harmful substances that enter the body through oxidation, reduction, hydrolysis, and conjugation actions, and expels them from the body.
Additionally, the liver also plays a role in detoxifying **ammonia** produced from the proteins ingested through the diet. When liver dysfunction occurs, ammonia can accumulate in the body, potentially causing brain disorders and hepatic encephalopathy.

Supporting liver function with placenta can enhance detoxification, contributing to anti-aging effects within the body. When liver function deteriorates, not only do toxins accumulate more easily, but the detoxification of medications may also be impaired, leading to limitations on the drugs that can be used and concerns about increased side effects. Placenta may be beneficial for pets currently showing liver value deterioration, those under long-term medication, or those about to undergo intensive treatment.

Providing information to support your pet’s health>>

For those concerned about their dog or cat’s liver and skin

If you are worried about your pet’s skin condition or liver health, or if your pet is already suffering from liver disease, please take a look at this page and the pages below for tips on restoring vitality and appetite.

At the Cordy Laboratory, we are also researching the application of Cordy, which is expected to modulate the immune system, and domestically-sourced SPF pig-derived placenta kiss powder in humans.

If you have any questions, please contact us.

監修獣医師：林美彩　　所属クリニック：chicoどうぶつ診療所

代替療法と西洋医学、両方の動物病院での勤務経験と多数のコルディの臨床経験をもつ。　モノリス在籍時には、一般的な動物医療（西洋医学）だけでは対応が困難な症例に対して多くの相談を受け、免疫の大切さを痛烈に実感する。
ペットたちの健康維持・改善のためには薬に頼った対処療法だけではなく、「普段の生活環境や食事を見直し、自宅でさまざまなケアを取り入れることで免疫力を維持し、病気にならない体づくりを目指していくことが大切である」という考えを提唱し普及活動に従事している。

所属：

• 獣医保健ソーシャルワーク協会

著書：

• 獣医師が考案した長生き犬ごはん 安心・簡単・作り置きOK!
• 獣医師が考案した長生き猫ごはん　安心・簡単・作り置きＯＫ！
• 獣医師が考案した一汁一菜長生き犬ごはん こだわりの安心レシピ&作り置きOK!